Open Targets MCP Server 🧬

A powerful, workflow-oriented Model Context Protocol (MCP) server for therapeutic discovery and drug repurposing. This server provides a seamless bridge between agentic AI platforms and the Open Targets Platform, leveraging its comprehensive GraphQL API.

🚀 Features

The server implements a suite of specialized tools for automated drug discovery:

Entity Resolution: Resolve common names (e.g., 'BRCA2', 'aspirin', 'asthma') to standardized identifiers (Ensembl, ChEMBL, EFO).
Target Prioritization: Retrieve top associated targets for any disease, ranked by multi-faceted association scores.
Safety Assessments: Quickly pull safety liabilities, toxicities, and risk information for gene/protein targets.
Pharmacovigilance: Access statistical FDA FAERS data (adverse events) for known drugs using log-likelihood ratios.
Druggability Analysis: View comprehensive tractability summaries for targets across multiple modalities (Small Molecule, Antibody, etc.).
Disease Phenotyping: Map diseases to their clinical signs and symptoms using the Human Phenotype Ontology (HPO).
Cancer Profiling: Retrieve cancer hallmarks (COSMIC) and gene essentiality scores from the Cancer Dependency Map (DepMap).
Animal Models: Access significant phenotypes observed in biological mouse models for human targets.

🛠 Tech Stack

Core: Python 3.10+
MCP Framework: FastMCP
API Interface: Open Targets GraphQL API (v4)
Runtime: HTTP/Streamable transport for modern agentic platforms.

📦 Installation & Setup

Clone the repository:

git clone <repository-url>
cd OpentargetMCP

Create and activate a virtual environment:

python3 -m venv .venv
source .venv/bin/activate

Install dependencies:
```
pip install -r requirements.txt
```
Run the server:
```
python server.py
```

🤖 Usage with AI Agents

To use this with an MCP-compatible agent (like Claude Desktop or Cursor), add the following to your configuration:

{
  "mcpServers": {
    "opentarget": {
      "command": "python",
      "args": ["/path/to/OpentargetMCP/server.py"]
    }
  }
}

📜 Example Questions

"Find repurposing candidates for Imatinib and identify its top associated diseases."
"What are the top therapeutic targets for Alzheimer's and their safety profiles?"
"Check the cancer essentiality of KRAS across various tissues."
"What are the clinical signs of Parkinson's Disease according to HPO?"

📄 License

MIT License

MCP Servers